Mood Support

True Cellular Formulas® Mood Support: A nutritional supplement containing nutrients and herbal extracts to support a healthy nervous system and a positive, balanced mood.

• This product promotes stress management by supplying essential vitamins and minerals for stress support, including B Vitamins, magnesium, and zinc. 1,✝
• Better brain chemistry: Anxiety and depression are often associated with an imbalance of neurotransmitters. Our exclusive blend including L-Theanine and valerian root supports balancing brain health. 2, 3✝
• Herbs like Rhodiola and Ashwagandha help to further manage stress and calm the nervous system 4,5✝

References:

1. Long SJ, Benton D. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. Psychosom Med. 2013 Feb;75(2):144-53. doi: 10.1097/PSY.0b013e31827d5fbd. Epub 2013 Jan 29. PMID: 23362497.
2. Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.
3. Jung HY, Yoo DY, Kim W, Nam SM, Kim JW, Choi JH, Kwak YG, Yoon YS, Hwang IK. Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC Complement Altern Med. 2014 Dec 11;14:476. doi: 10.1186/1472-6882-14-476. PMID: 25495725; PMCID: PMC4364108.
4. Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13. doi: 10.4314/ajtcam.v8i5S.9. Epub 2011 Jul 3. PMID: 22754076; PMCID: PMC3252722.
5. Li Y, Pham V, Bui M, Song L, Wu C, Walia A, Uchio E, Smith-Liu F, Zi X. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. 2017 Dec;3(6):384-395. doi: 10.1007/s40495-017-0106-1. Epub 2017 Sep 14. PMID: 30393593; PMCID: PMC6208354.

 

Other Supportive Research 

• Butterworth RF. Thiamin deficiency and brain disorders. Nutr Res Rev. 2003 Dec;16(2):277-84. doi: 10.1079/NRR200367. PMID: 19087395.
• Marashly ET, Bohlega SA. Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine. Front Neurol. 2017 Jul 20;8:333. doi: 10.3389/fneur.2017.00333. PMID: 28775706; PMCID: PMC5517396.
• Gasperi V, Sibilano M, Savini I, Catani MV. Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Int J Mol Sci. 2019 Feb 23;20(4):974. doi: 10.3390/ijms20040974. PMID: 30813414; PMCID: PMC6412771.
• Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. PMID: 26828517; PMCID: PMC4772032.
• Cuciureanu MD, Vink R. Magnesium and stress. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011. 
• Pfeiffer CC, Braverman ER. Zinc, the brain and behavior. Biol Psychiatry. 1982 Apr;17(4):513-32. PMID: 7082716.
• Hieu TH, Dibas M, Surya Dila KA, Sherif NA, Hashmi MU, Mahmoud M, Trang NTT, Abdullah L, Nghia TLB, Y MN, Hirayama K, Huy NT. Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: A systematic review and meta-analysis of randomized trials and quasi-randomized trials. Phytother Res. 2019 Jun;33(6):1604-1615. doi: 10.1002/ptr.6349. Epub 2019 Apr 21. PMID: 31006899.
• Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020 Sep 17;14:923. doi: 10.3389/fnins.2020.00923. PMID: 33041752; PMCID: PMC7527439.
• Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, Kras M, Scholz C, Sass M, Buchwald-Werner S. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014 Oct 30;6(11):4805-21. doi: 10.3390/nu6114805. PMID: 25360512; PMCID: PMC4245564.
• Brock C, Whitehouse J, Tewfik I, Towell T. American Skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res. 2014 May;28(5):692-8. doi: 10.1002/ptr.5044. Epub 2013 Jul 22. PMID: 23878109.
• Lim DW, Han T, Jung J, Song Y, Um MY, Yoon M, Kim YT, Cho S, Kim IH, Han D, Lee C, Lee J. Chlorogenic Acid from Hawthorn Berry (Crataegus pinnatifida Fruit) Prevents Stress Hormone-Induced Depressive Behavior, through Monoamine Oxidase B-Reactive Oxygen Species Signaling in Hippocampal Astrocytes of Mice. Mol Nutr Food Res. 2018 Jun 12:e1800029. doi: 10.1002/mnfr.201800029. Epub ahead of print. PMID: 29893510.
• Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013 Aug;16(4):313-26. doi: 10.1089/rej.2013.1431. PMID: 23772955; PMCID: PMC3746283.
• Zhu S, Liu F, Zhang R, Xiong Z, Zhang Q, Hao L, Chen S. Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders. Front Pharmacol. 2022 Jun 16;13:857449. doi: 10.3389/fphar.2022.857449. PMID: 35784755; PMCID: PMC9244706.
• Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna-Å»ydecka K. Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review. Nutrients. 2020 Dec 19;12(12):3894. doi: 10.3390/nu12123894. PMID: 33352740; PMCID: PMC7766837.
• Jung HY, Yoo DY, Kim W, Nam SM, Kim JW, Choi JH, Kwak YG, Yoon YS, Hwang IK. Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC Complement Altern Med. 2014 Dec 11;14:476. doi: 10.1186/1472-6882-14-476. PMID: 25495725; PMCID: PMC4364108.
• Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30. PMID: 17182482.
• Kennedy DO, Bonnländer B, Lang SC, Pischel I, Forster J, Khan J, Jackson PA, Wightman EL. Acute and Chronic Effects of Green Oat (Avena sativa) Extract on Cognitive Function and Mood during a Laboratory Stressor in Healthy Adults: A Randomised, Double-Blind, Placebo-Controlled Study in Healthy Humans. Nutrients. 2020 May 29;12(6):1598. doi: 10.3390/nu12061598. PMID: 32485993; PMCID: PMC7352613.
• Pathania R, Chawla P, Khan H, Kaushik R, Khan MA. An assessment of potential nutritive and medicinal properties of Mucuna pruriens: a natural food legume. 3 Biotech. 2020 Jun;10(6):261. doi: 10.1007/s13205-020-02253-x. Epub 2020 May 20. PMID: 32477848; PMCID: PMC7239958.
• Peterson B, Nguyen H. St. John's Wort. [Updated 2022 May 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.
• Fukuda T, Ohnuma T, Obara K, Kondo S, Arai H, Ano Y. Supplementation with Matured Hop Bitter Acids Improves Cognitive Performance and Mood State in Healthy Older Adults with Subjective Cognitive Decline. J Alzheimers Dis. 2020;76(1):387-398. doi: 10.3233/JAD-200229. PMID: 32474473; PMCID: PMC7369117.
• Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020 Dec 26;22(1):181. doi: 10.3390/ijms22010181. PMID: 33375373; PMCID: PMC7796270.

† STATEMENTS ON THIS WEBSITE HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. PRODUCTS ARE NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.